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目的了解北京市石景山区人群血尿酸水平和高尿酸血症(Hyperuricemia,HUA)患病状况及与性别、年龄等慢病危险因素的关系。方法对北京市石景山区居民进行成人HUA患病及危险因素调查,测定血尿酸、血糖及血脂水平,测量血压、身高、体质量及腰围,分析血尿酸水平与慢性病及危险因素之间的关系。结果血尿酸水平各年龄段男性均高于女性(t=17.16,P<0.05),女性血尿酸随的年龄升高而升高,差异有统计学意义(t=19.60,P<0.05)。血尿酸水平与高血压、血脂异常、心脑血管病、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和超重肥胖相关。HUA患病率为6.42%,其中男性患病率8.03%,高于女性的4.86%,差异有统计学意义(χ~2=20.561,P<0.001)。根据logistic回归分析,男性、饮酒、高TG、低HDL-C是HUA危险因素。结论血尿酸水平与血脂异常、高血压、肥胖等慢病相关,且与吸烟、饮酒等生活方式有关。改善生活方式和饮食习惯,对降低血尿酸水平及预防心脑血管病是有益的。
Objective To understand the prevalence of serum uric acid, the prevalence of hyperuricemia (HUA) and the risk factors of chronic diseases such as gender and age in Shijingshan District of Beijing. Methods The prevalence and risk factors of HUA in adults in Shijingshan District of Beijing were investigated. The levels of serum uric acid, blood glucose and blood lipid were measured. The blood pressure, height, body mass and waist circumference were measured. The relationship between serum uric acid level and chronic diseases and risk factors was analyzed. Results The level of serum uric acid in all age groups was higher than that in women (t = 17.16, P <0.05). The serum uric acid increased with the increase of age in women. The difference was statistically significant (t = 19.60, P <0.05). Serum uric acid levels are associated with hypertension, dyslipidemia, cardio-cerebrovascular disease, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and overweight and obesity. The prevalence of HUA was 6.42%, of which the prevalence was 8.03% in males and 4.86% in females, the difference was statistically significant (χ ~ 2 = 20.561, P <0.001). According to logistic regression analysis, male, alcohol consumption, high TG, low HDL-C were risk factors for HUA. Conclusion The serum uric acid level is related to chronic diseases such as dyslipidemia, hypertension and obesity, and is related to lifestyles such as smoking and drinking. Improve lifestyle and eating habits, to reduce blood uric acid levels and prevent cardiovascular disease is beneficial.