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硝苯吡啶(Nifedipine)是目前正在美国进行临床试验用的一种钙拮抗剂,以往的研究提示,硝苯吡啶是一种治疗冠状动脉痉挛的有效制剂,但尚缺少双盲试验的对照观察。本文应用双盲试验法,比较硝苯吡啶和二硝酸异山梨醇酯治疗冠状动脉痉挛所致心绞痛的疗效。方法:12例患者,女性10例,男性2例。所有病例在临床上均有静息时发作的胸痛,伴有≥0.1毫伏的 ST 段变化和可逆性局部冠状动脉痉挛。5例为右冠状动脉痉挛,7例为左前降支痉挛。试验观察包括三期。第Ⅰ期为历时2周的治疗前观察期,估计心绞痛发作次数和硝酸甘油片的用量。第Ⅱ期为时5周,随机双盲分为以硝苯吡啶作为治疗
Nifedipine is a calcium antagonist currently being used in clinical trials in the United States. Previous studies suggested that nifedipine is an effective agent for the treatment of coronary artery spasm but there is a lack of a controlled double-blind trial. In this paper, double-blind trial was used to compare the efficacy of nifedipine and isosorbide dinitrate in the treatment of angina pectoris caused by coronary artery spasm. Methods: Twelve patients, 10 females and 2 males. All cases were clinically clinically symptomatic chest pain with ST segment changes ≥ 0.1 mV and reversible focal coronary artery spasm. 5 cases of right coronary artery spasm, 7 cases of left anterior descending artery spasm. Experimental observation includes three phases. The first period is 2 weeks before the observation period, the estimated number of episodes of angina and nitroglycerin tablets. The second period of 5 weeks, randomized double-blind to nifedipine as a treatment