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目的:探讨手足口病重症患儿恢复期中枢神经系统(CNS)症状反复病例的临床特点。方法:收集并分析大连市儿童医院2010年1月至12月收治的6例手足口病重症患儿恢复期CNS症状反复病例的临床资料。结果:6例患儿均为肠道病毒71型(EV71)感染,第1次出现CNS症状体征的时间为病程1～4d(平均2.3d),出现CNS症状反复的时间为病程14～23d(平均17.2d),两次神经系统症状表现相似。所有患儿给予甲泼尼龙抗炎、降颅压、丙种球蛋白、抗感染等综合治疗后均痊愈,无后遗症。结论:手足口病重症患儿恢复期可出现CNS症状反复,早发现、早期再次给予常规治疗后,预后较好。
Objective: To investigate the clinical features of recurrent cases of central nervous system (CNS) symptoms in convalescent hand-foot-mouth disease children. Methods: The clinical data of 6 cases of severe CNH handicapped children with convalescent CNS recovered from Dalian Children’s Hospital from January 2010 to December 2010 were collected and analyzed. Results: All of the 6 children were infected with EV71. The first symptoms and signs of CNS were 1 ~ 4 days (mean 2.3 days). The symptoms of CNS recurrence were 14 ~ 23 days Average 17.2d), two similar symptoms of neurological symptoms. All children given methylprednisolone anti-inflammatory, reducing intracranial pressure, gamma globulin, anti-infective and other comprehensive treatment were cured, no sequelae. CONCLUSIONS: CNS symptoms may occur repeatedly during the convalescence of children with HFMD, and early detection of CNS symptoms may be helpful.