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本研究以新西兰品系实验兔为动物模型，观察人重组－γ干扰素（ｈｒＩＦＮ－γ）的抗生育效应并探讨其作用机理。实验结果：ｈｒＩＦＮ－γ能降低兔胚泡的着床率，对照组的着床率为８０％，ｈｒＩＦＮ－γ２．５、５．０和１０万ＩＵ３组的着床率分别为３０％、２７％和２７％。检测血清中雌二醇（Ｅ２）水平，对照组为１５７．９±３１．８ｐｍｏｌ／Ｌ，ｈｒＩＦＮ－γ各组均有降低趋势，分别为１０７．３±１９．２、１０６．３±２１．７和１０４．９±１９．８０ｐｍｏｌ／Ｌ；血清孕酮（Ｐ）水平，对照组为５０．５９±７．６２ｎｍｏｌ／Ｌ，ｈｒＩＦＮ－γ各组分别为１０．２１±３．１８、６．２３±１．６４和４．８７±０．２６ｎｍｏｌ／Ｌ。在对卵巢和子宫组织的实验病理学的系统观察发现，ｈｒＩＦＮ－γ剂量为１０万ＩＵ时，呈明显的黄体退化、子宫内膜的发育及内膜上皮和腺体的分泌均被抑制。研究表明ｈｒＩＦＮ－γ对孕兔有一定的抗生育效应，其抗孕作用的主要靶器官可能是卵巢，从而影响子宫内环境，使不利于妊娠
In this study, New Zealand strain experimental rabbit was used as an animal model to observe the anti-fertility effect of human interferon-gamma interferon (hrIFN-γ) and to explore its mechanism. The experimental results: hrIFN-γ can reduce the implantation rate of rabbit blastocysts, the implantation rate of the control group was 80%, the implantation rate of hrIFN-γ2.5, 5.0 and 100,000 IU3 group were 30%, 27 % And 27%. Serum E2 levels were detected in the control group (157.9 ± 31.8pmol / L, hrIFN-γ), with a decreasing tendency of 107.3 ± 19.2 and 106.3 ± 21 respectively. 7 and 104.9 ± 19.80pmol / L, respectively. The level of serum progesterone (P) was 50.59 ± 7.62nmol / L in control group and 10.21 ± 3.18,6 in hrIFN-γ group respectively. 23 ± 1.64 and 4.87 ± 0.26 nmol / L. A systematic observation of the experimental pathology of ovarian and uterine tissues revealed a marked luteal degeneration at a dose of 100,000 IU hrhr, with the development of the endometrium and the secretion of endometrial epithelium and glands suppressed. Studies have shown that hrIFN-γ on pregnant rabbits have a certain anti-fertility effect, the main target organ of anti-conception may be the ovary, thus affecting the uterine environment, so that is not conducive to pregnancy