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LHRH-PE40是通过融合蛋白技术产生的,由绿脓杆菌外毒素A(PE40)基因和促黄体激素释放激素(LHRH)基因重组后在大肠杆菌中表达出的一种嵌合蛋白。大量实验表明,某些肿瘤细胞表面过多表达LHRH受体,而相应的正常组织和细胞表面几乎测不到该受体。借助这个特点,将嵌合蛋白内的PE40由L
LHRH-PE40 is a chimeric protein produced by fusion protein technology and expressed in E. coli after recombination of the Pseudomonas exotoxin A (PE40) gene and the luteinizing hormone releasing hormone (LHRH) gene. A large number of experiments show that some tumor cells overexpress LHRH receptors on the surface, while the corresponding normal tissues and cell surfaces barely detect the receptor. With this feature, the PE40 in the chimeric protein consists of L