p53基因是重要的肿瘤抑制基因,许多人类肿瘤都伴有不同程度的p53基因突变。既往研究提示,口腔癌的发生、发展与p53基因突变有一定关系。本文采用聚合酶链反应-单链构象多态性分析(poly-merase chain reaction-single strand conformationpolymorphism,PCR-SSCP)结合DNA核酸序列 p53 gene is an important tumor suppressor gene, many human tumors are associated with varying degrees of p53 gene mutation. Previous studies suggest that the occurrence and development of oral cancer have a certain relationship with p53 gene mutation. In this paper, poly-merase chain reaction-single strand conformation polymorphism (PCR-SSCP) combined with DNA nucleic acid sequence