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C-反应蛋白(CRP)是在正常血清中有少量存在,感染、炎症、组织坏死和恶性肿瘤时显著增加的一种急性相反应蛋白。本文拟就CRP的生物学特点、生理及病理效应以及其在儿科临床上的应用作一综述。 CRP的生物学特点 CRP有5个相同的亚基,通过非共价键聚合在一起,其分子量为120,000～140,000道尔顿,沉降系数为7.5S。电泳迁移率则随使用的方法不同而表现出不同的特征。1968年,Nelson用免疫扩散法最先证明健康献血员的血清中,50～70％的人有微量CRP。正常人和疾病中出现的CRP在性质上相同。一般认为,CRP系由肝脏细胞产生。在急性炎症或组织损伤后数小时,肝脏合成和分泌CRP的速度增加,24～48小时内血清可达300mg/L的高值。其确切机制尚不清楚,可能与体液因素如白细胞释放的内源
C-reactive protein (CRP) is an acute phase-response protein that is significantly increased in normal serum in the presence of small amounts, infections, inflammation, tissue necrosis and malignancy. This article intends to review the biological characteristics, physiological and pathological effects of CRP and its clinical application in pediatrics. Biological characteristics of CRP CRP has five identical subunits, aggregated together by non-covalent molecular weight of 120,000 to 140,000 Daltons, sedimentation coefficient of 7.5S. Electrophoretic mobility then varies depending on the method used. In 1968, Nelson first demonstrated by immunodiffusion that 50-70% of sera from healthy blood donors had a trace amount of CRP. The CRP that occurs in normal subjects and in disease is qualitatively identical. It is generally believed that CRP is produced by liver cells. Hours after acute inflammation or tissue injury, the liver synthesizes and secretes more CRP, with serum levels reaching 300 mg / L in 24-48 hours. The exact mechanism is unclear and may be related to humoral factors such as the endogenous release of leukocytes