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Since 2-aminonicotinic acid is a zwitterionic molecule,the salt or co-crystal strategy was used for the precipitation under identical conditions and obtained two novel salts: salt 1 with 2:1:2 stoichiometry of 2-aminonicotinic acid:perchloric acid:H_2O and salt 2 with 2:1:3 stoichiometry of 2-aminonicotinic acid:sulfuric acid:H_2O. Their crystal structures were characterized by single-crystal X-ray diffraction,differential scanning calorimetry(DSC) and thermogravimetric analyses(TGA). The structure determination shows that two salts are both primarily stabilized by the strong N–H···O hydrogen bonding interaction between 2-aminonicotinic acid and its corresponding acids. Constituents of the salt-crystalline phase were also investigated in terms of Hirshfeld surfaces. In the crystal lattice,a three-dimensional hydrogen-bonded network is observed,including the formation of a two-dimensional molecular scaffolding motif. Hirshfeld surfaces and fingerprint plots of two salts show that the structures are stabilized by H···H,O–H···O and C–O···π intermolecular interactions.
Since 2-aminonicotinic acid is a zwitterionic molecule, the salt or co-crystal strategy was used for the precipitation under identical conditions and obtained two novel salts: salt 1 with 2: 1: 2 stoichiometry of 2-aminonicotinic acid: perchloric acid: H 2 O Their crystal structures were characterized by single-crystal X-ray diffraction, differential scanning calorimetry (DSC) and thermogravimetric analyzes (TGA). The structure of 2-aminonicotinic acid Determination shows that both salts are both stabilized by the strong N-H ··· O hydrogen bonding interaction between 2-aminonicotinic acid and its corresponding acids. Constituents of the salt-crystalline phase were also investigated in terms of Hirshfeld surfaces. In the crystal lattice, a three-dimensional hydrogen-bonded network is observed, including the formation of a two-dimensional molecular scaffolding motif. Hirshfeld surfaces and fingerprint plots of two salts show that t he structures are stabilized by H ··· H, O-H ··· O and C-O ··· intermolecular interactions.