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慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)以部分可逆的进行性气流受限以及持续存在的慢性支气管炎症为特征。吸烟为其发生、发展的主要危险因素,戒烟被认为是延缓肺功能下降的主要措施,但戒烟对COPD慢性气道炎症的确切作用尚不清楚。多数研究证实,COPD患者戒烟后气道慢性炎症仍然存在,强调早期戒烟相当重要。本研究探讨不同阶段戒除烟雾刺激对大鼠慢性支气管炎炎症过程的影响。
Chronic obstructive pulmonary disease (COPD) is characterized by a partially reversible progressive airflow restriction and the persistence of chronic bronchial inflammation. Smoking is the main risk factor for its occurrence and development. Quitting smoking is considered as the main measure to delay the decline of lung function. However, the exact role of smoking cessation in chronic airway inflammation in COPD remains unclear. Most studies confirm that COPD patients still have chronic airway inflammation after quitting smoking, emphasizing the importance of early quitting smoking. This study explored the different stages of smoking to eliminate the impact of chronic inflammation in rats with bronchitis process.