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作者观察了25例(男10例,女15例,15-70岁)未经化疗,放疗,未接触过苯及其他毒物的初期MDS患者转变为急非淋白血病(ANL)后的强烈化疗效果。21例开始即合用DNR(红比霉素,50岁以下50mg/m~2,60岁以上30mg/m~2×3天)和Ara-C(200mg/m~2×7天),其中2例于第2疗程,1例于第3疗程改为先给Ara-C(3g/m~2)6小时后再给MTZ(米托蒽醌,mitoxantrone,7mg/m~2)的方案。有4例开始就单用大剂量Ara-C,共6天。结果:6例获完全缓解(24%),并改为每月1疗程维持量治疗;3例用DNR
The authors observed a strong chemotherapeutic response in 25 patients (10 males, 15 females, 15-70 years of age) who had not undergone chemotherapy, radiotherapy, initial MDS without exposure to benzene and other poisons to acute non-leukemia (ANL) . In the 21 cases, DNR (rubenicidin, 50mg / m ~ 2 years old, 30mg / m ~ 2 × 3 days of 60 years old and above) and Ara-C (200mg / m ~ 2 × 7 days) In the second course of treatment, 1 case of the third course of treatment to give Ara-C (3g / m ~ 2) 6 hours after MTZ (mitoxantrone, mitoxantrone, 7mg / m ~ 2) program. Four patients started on a single dose of Ara-C for 6 days. Results: Six patients achieved complete remission (24%) and were treated with 1 course of maintenance monthly. Three patients were treated with DNR