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多年来,对红细胞功能的了解仅局限于它是高度分化的含有血红蛋白的细胞气体交换载体。1981年Siegel 等提出了红细胞免疫系统的新概念,观察到灵长类动物和兔类等红细胞膜上有抗原-抗体补体复合物的粘着(即红细胞免疫粘着-RCIA),奠定了红细胞免疫基础,推动和革新了红细胞功能的理论。揭示了机体免疫系统不可忽视的部分即红细胞免疫系统。根据 Siegel 等红细胞免疫粘附(RCIA)试验原理,
Over the years, the understanding of erythrocyte function has been limited to the highly differentiated hemoglobin-containing cell gas exchange carrier. In 1981, Siegel et al. Proposed a new concept of erythrocyte immune system. The adhesion of antigen-antibody complement complex (ie erythrocyte immune adhesion-RCIA) was observed on erythrocyte membrane such as primate and rabbit, which laid the foundation of erythrocyte immunity. Promote and reform the theory of erythrocyte function. Revealed the body’s immune system can not be ignored that part of the red blood cell immune system. According to Siegel and other red blood cell immune adhesion (RCIA) test principle,