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目的探讨血清胱抑素C(Cys C)在早期诊断造影剂肾病(CIN)中的临床意义。方法 100例行血管造影的患者为研究对象,根据造影前后血清肌酐(Scr)值的变化分为CIN组和非CIN组,每组50例。分别检测两组造影前24 h内、造影后8、24、48 h Cys C的水平,对比两组造影前后血清Cys C的变化情况,评估Cys C在CIN早期诊断中的价值。结果 CIN组患者的血清Cys C在造影后8 h时开始升高,24 h达高峰,随后下降,与造影前比较,差异有统计学意义(P<0.05);与非CIN组相应时间点相比,CIN组患者的血清Cys C也显著增高,差异有统计学意义(P<0.05);且CIN组患者的血清Cys C在造影前及造影后24 h与相应时间点的血清肌酐呈正相关(r=0.870、0.715)。结论在CIN患者中,血清Cys C能比血肌酐更早地反映肾功能的损害,值得临床推广应用。
Objective To investigate the clinical significance of serum cystatin C (Cys C) in the early diagnosis of contrast-induced nephropathy (CIN). Methods 100 patients who underwent angiography were divided into CIN group and non-CIN group according to the change of serum creatinine (Scr) before and after angiography, 50 cases in each group. The levels of Cys C at 8, 24, and 48 h after angiography were detected within 24 hours before angiography. The changes of serum Cys C before and after angiography were compared to evaluate the value of Cys C in the early diagnosis of CIN. Results Serum Cys C of patients in CIN group increased at 8 h after angiography and peaked at 24 h, then decreased significantly compared with that before angiography (P <0.05). Compared with non-CIN group, the level of Cys C (P <0.05). Serum Cys C in CIN group was positively correlated with serum creatinine at 24 h before and after angiography (P <0.05), while serum Cys C in CIN group was significantly higher than that in CIN group r = 0.870, 0.715). Conclusion In patients with CIN, serum Cys C can reflect renal function damage earlier than serum creatinine, which is worthy of clinical application.