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急性 HIV 感染常伴随病毒的明显上升,然后迅速下降,关于体液和细胞免疫性在病毒最初复制的控制中所起的作用目前还不清楚。数月前我们在7例血浆中有 CD8T 细胞不自溶细胞抗 HIV 活性的 HIV 感染者标本中发现中性抗体。在其中的一些标本中观察到 CD8T 细胞反应的范围与血浆病毒血症的水平逆相关。该结果提示在 HIV 感染后细胞免疫反应很快控制病毒复制。
Acute HIV infection often accompanied by a marked increase in the virus, and then decreased rapidly, the role of humoral and cellular immunity in the control of the initial replication of the virus is unclear. A few months ago we found neutral antibodies in 7 HIV-infected subjects with CD8 T cells that did not self-lyse HIV antigens in plasma. The extent of CD8 T cell responses observed in some of these samples was inversely correlated with the level of plasma viremia. This result suggests that cellular immune responses quickly control viral replication after HIV infection.