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灼口综合征(burning mouth syndrome,BMS)和牙髓疼痛作为口腔神经和炎症疼痛疾病的代表,其机制尚不明确。研究显示,其很可能与钠离子通道有关,尤其是NaⅤ1.7。NaⅤ1.7活化的突变可导致极度疼痛,而NaⅤ1.7失活的突变可产生无痛症。目前少有关于NaⅤ1.7在疼痛部位表达情况的
Burning mouth syndrome (BMS) and dental pulp pain are representative of diseases of the oral nerves and inflammatory pains and the mechanism is not clear. Studies have shown that it is likely related to sodium ion channels, especially NaV1.7. Mutations that activate NaV1.7 can cause extreme pain, while mutations that inactivate NaV1.7 can produce painlessness. At present there is little about the expression of NaV1.7 in the pain area