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近年来发现萎缩性胃炎低胃酸老年人可有小肠上段细菌定植,但是否引起吸收不良则尚未肯定。作者对临床和实验室检查均正常的健康老年志愿者,先作血清胃蛋白酶原Ⅰ和Ⅱ测定,其比值<2.9和>4.0的各有10例。比值<2.9者中9例作胃泌素刺激试验,其中8例证实有低胃酸,肠液的细菌培养表明有细菌过度生长(≥10~6CFU/ml),男3、女6,平均年龄70.2±1.5,作为萎缩性胃炎组;比值>4.0者给予口服奥美拉唑40 mg/d,内8例肠液培养亦示细菌生长过度,男4、女4,平均年龄88.9±1.8,作为奥美拉唑组。另16例健康老人,血
In recent years found that atrophic gastritis in patients with upper gastrointestinal upper gastrointestinal bacteria may colonization, but whether caused by malabsorption is yet to be sure. The author of the clinical and laboratory tests were normal healthy elderly volunteers, first for serum pepsinogen Ⅰ and Ⅱ measured, the ratio of <2.9 and> 4.0 in each of 10 cases. Nine patients in the ratio <2.9 were tested for gastrin stimulation. Eight of them showed low gastric acidity. Bacterial culture of intestinal fluid showed bacterial overgrowth (≥10 ~ 6CFU / ml), male 3 and female 6, mean age 70.2 ± 1.5, as atrophic gastritis group; ratio> 4.0 were given oral omeprazole 40 mg / d, 8 cases of intestinal fluid culture also showed bacterial overgrowth, male 4, female 4, mean age 88.9 ± 1.8, Azole group. Another 16 healthy elderly, blood