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目的评价不同治疗方案治疗成人大骨节病患者的治疗效果,为选择新的方法提供依据。方法按随机对照方法,选择确诊的成人大骨节病患者并将其分成两组,分别用中医药二联疗法和西医经典疗法进行治疗,治疗前后分别用SF-36量表进行问卷调查。结果经3个月治疗,中医药二联疗法治疗组生理机能PF得分为70.88±24.57、西医组得分58.57±21.58(P<0.05);生理职能RP中医组得分66.18±42.59,西医组38.57±43.45(P<0.05);躯体疼痛BP中医组得分65.81±22.89,西医组得分49.29±21.85(P<0.01);一般健康状况GH中医组得分46.32±20.68,西医组35.00±23.51(P<0.05);情感职能MH中医组得分82.35±36.91,西医组49.52±49.42(P<0.01)。结论中医药二联疗法方案对大骨节病患者生理机能、生理职能、躯体疼痛、情感职能及一般健康状况改善作用优于硫酸软骨素配维生素E组合,是一种具有良好临床应用价值的治疗方案;SF一36量表具有多维疗效评价作用,可用于大骨节病患者的生命质量评价。
Objective To evaluate the therapeutic effect of different treatment regimens in treating patients with adult Kashin-Beck disease and provide the basis for selecting new methods. Methods According to randomized controlled trials, patients with adult Kashin-Beck disease were selected and divided into two groups. The patients were treated with traditional Chinese medicine combined therapy and western medicine respectively. Before and after treatment, questionnaires were conducted using SF-36 scale. Results After 3 months of treatment, the score of physical function PF was 70.88 ± 24.57 in TCM combined therapy group and 58.57 ± 21.58 in Western medicine group (P <0.05), and the score of Chinese medicine group was 66.18 ± 42.59 and 38.57 ± 43.45 in Western medicine group (P <0.05). The pain score of Chinese medicine group was 65.81 ± 22.89 and that of Western medicine group was 49.29 ± 21.85 (P <0.01). The score of Chinese medicine group was 46.32 ± 20.68 in general health condition and 35.00 ± 23.51 in Western medicine group (P <0.05). The emotional function MH Chinese medicine group score 82.35 ± 36.91, Western medicine group 49.52 ± 49.42 (P <0.01). Conclusion The Chinese medicine dual therapy regimen is superior to chondroitin sulfate combined with vitamin E in the treatment of patients with Kashin-Beck disease, and its effect on physiology, physiology, physical function, body pain, emotional function and general health status is a kind of treatment plan with good clinical value ; SF-36 scale with multidimensional curative effect evaluation, can be used for the quality of life of patients with Kashin-Beck disease.