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目的观察草酸铂(OXA)联合亚叶酸钙(CF)和5-氟尿嘧啶(5-Fu)组成OLF方案治疗晚期胃癌的临床疗效和不良反应。方法收治晚期胃癌患者30例,采用OXA 130 mg/m2静脉滴注2 h,第1天,CF 75 mg/m2静脉滴注2 h后,5-Fu 300 mg/m2(≤500 mg/d)静脉滴注4 h,1~5 d。结果PR14例、SD 11例、PD5例,有效率46.7%(14/30)。主要不良反应为感觉神经毒性、骨髓抑制,无化疗相关死亡。结论以OXA为主组成OLF方案治疗晚期胃癌疗效较好,耐受性良好。
Objective To observe the clinical efficacy and side effects of oxaliplatin (OXA) plus leucovorin (CF) and 5-fluorouracil (5-Fu) in the treatment of advanced gastric cancer. Methods Thirty patients with advanced gastric cancer were enrolled in this study. OXA 130 mg / m2 was given intravenously for 2 hours. On the first day, 5-Fu 300 mg / m2 (≤ 500 mg / Intravenous infusion of 4 h, 1 ~ 5 d. Results PR 14 cases, SD 11 cases, PD 5 cases, the effective rate was 46.7% (14/30). The main adverse reactions were sensory neurotoxicity, myelosuppression, and no chemotherapy-related death. Conclusion OXA-based OLF regimen is effective and well tolerated in the treatment of advanced gastric cancer.