Using an emulsification-gelation method,chitosansodium alginate-porcine hemoglobin microcapsules were prepared.Results show that these microcapsules have better forms and small granules with 1 μm size of the mean particle size.They possess a relatively narrow and normal Gaussian distribution.The loading efficiency of porcine hemoglobin (pHb) in microcapsules is more than 90%.The pHb released from microcapsules is extended for more than one month.Chitosan-sodium alginate-hemoglobin microcapsules are expected to become an artificial oxygen-carrying therapeutic agent with sustained release for intravenous injection.