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Dear Editor,rnResearchers reported an association between vasectomy and primary progressive aphasia (PPA—a rare variety of ffontotemporal dementia) in a 2006 manuscript in Cognitive Behavioral Neurology detailing a case-control study that compared 47 men with the disease to 57 controls.1 The rate of vasectomy in PPA patients was 40% (19/47) vs.16% (9/57) in normal controls.This difference met statistical significance (P=0.02).The study also found that there was a younger age of PPA onset for patients who had undergone vasectomy (58.8 vs.62.9 years;P=0.03).