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目的:比较依那普利与卡托普利对原发性高血压患者降压的临床疗效。方法:选取2013年3月—2015年3月间收治的原发性高血压患者126例的临床资料,将其按照随机数字表法分为治疗组与对照组,每组63例;对照组患者给予卡托普利片降压治疗,治疗组患者给予依那普利降压治疗,比较两组患者用药后降压的临床效果。结果:治疗组患者治疗后的总有效率为95.24%高于对照组为79.36%(P<0.05);治疗前两组患者血压各指标测得值经比较其差异无统计学意义(P>0.05);治疗后两组患者血压各指标测得值均优于对照组(P<0.05);治疗组患者用药后不良反应的发生率为4.76%低于对照组为25.40%(P<0.05)。结论:依那普利用于治疗原发性高血压患者,降压效果较为显著,能改善患者血压水平,不良反应的发生率低,安全性高,其降压作用优于卡托普利。
Objective: To compare the clinical efficacy of enalapril and captopril in lowering blood pressure in patients with essential hypertension. Methods: The clinical data of 126 patients with essential hypertension treated in our hospital from March 2013 to March 2015 were selected and divided into treatment group and control group according to the random number table method, with 63 patients in each group. Patients in the control group Antihypertensive treatment was given to captopril, and enalapril was given to the patients in the treatment group for antihypertensive treatment. The clinical effects of antihypertensive drugs were compared between the two groups. Results: The total effective rate of treatment group after treatment was 95.24% higher than that of control group (79.36%, P <0.05). There was no significant difference between the two groups before treatment (P> 0.05 ). After treatment, the measured values of blood pressure in both groups were better than those in the control group (P <0.05). The incidence of adverse reactions in the treatment group was 4.76% lower than that in the control group (25.40%, P <0.05). Conclusion: Enalapril is effective in lowering blood pressure in patients with essential hypertension. It can improve the blood pressure of patients with low incidence of adverse reactions and high safety, and its antihypertensive effect is better than captopril.