论文部分内容阅读
目的探讨食管测压和２４ｈｐＨ监测在国人胃食管反流病（ＧＥＲＤ）诊断中的价值．方法无症状志愿者１０３例和有典型胃食管反流（ＧＥＲ）症状者１０６例同期进行食管测压和２４ｈｐＨ监测．结果无症状志愿者组食管下括约肌（ＬＥＳ）静息压（ＬＥＳＰ）３１ｋＰａ±１０ｋＰａ；ＬＥＳ长度（ＬＥＳＬ）３０ｃｍ±０５ｃｍ；松弛时间（ＬＥＳＲＤ）６８ｓ±１１ｓ；食管中下段蠕动传导速度（ＭＬＰＶ）４２ｃｍ／ｓ±０９ｃｍ／ｓ；异常收缩发生率（ＰＡＣ）４％±２％，与ＧＥＲ症状组比较（ＬＥＳＰ１９ｋＰａ±０９ｋＰａ；ＬＥＳＬ１４ｃｍ±０５ｃｍ；ＬＥＳＲＤ８２ｓ±１２ｓ；ＭＬＰＶ３１ｃｍ／ｓ±１０ｃｍ／ｓ；ＰＡＣ１０％±１５％）差异均有显著性（Ｐ＜００５）．以ｘ±２ｓ确定正常值，ＧＥＲ症状组总异常率为４７％．上述测压５项指标中３项以上异常时，高度提示抗反流屏障受损及存在病理性反流．根据９５例健康人食管ｐＨ监测９５％正常值，ｐＨ＜４总时间百分率（Ｎ＜４０％）和反流总计分（Ｎ＜１４分）两项指标诊断ＧＥＲＤ的敏感性分别达９５１％和９６７％；特异性均为９６８％．反流总计分联合最长反流持续时间（Ｎ＜１４ｍｉｎ）?
Objective To investigate the value of esophageal manometry and 24hpH monitoring in the diagnosis of gastroesophageal reflux disease (GERD) in Chinese. Methods 103 cases of asymptomatic volunteers and 106 cases of typical gastroesophageal reflux (GER) symptoms were monitored by esophageal manometry and 24hpH at the same time. Results Asymptomatic volunteers underwent LESP 3 1 kPa ± 1 0 kPa; LESL 3 0 cm ± 0 5 cm; relaxation time (LESRD) 6 8 s ± 1 1s; the rate of peristaltic conduction (MLPV) in the middle and lower esophagus was 42cm / s ± 09cm / s; the rate of abnormal contraction (PAC) was 4% ± 2%, compared with the GER symptom group (LESP19kPa ± 09kPa; LESL14cm ± 05cm; LESRD82s ± 12s; MLPV31cm / s ± 10cm / s; PAC10% ± 15%) were significantly different (P <005). The normal value of x ± 2s, the total abnormal rate of GER symptoms was 47%. In the above five indicators of the three indicators of abnormal above, highly suggestive of anti-reflux barrier damage and the presence of pathological reflux. According to the 95% normal values of esophageal pH monitoring in 95 healthy people, the sensitivity of GERD to 95% of the total time points (N <40%) and reflux total score (N <14 points) was 95% 1% and 96.7% respectively; the specificity was 96.8%. Total reflux combined longest duration of reflux (N <14min)?