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目的:研究甘草次酸对大鼠体内山奈酚药物动力学的影响。方法:将78只SD大鼠,随机分成4组,雌雄各半,即高浓度实验组与低浓度实验组及对照组的高浓度组与低浓度组,每组中又包括三个小组即1h、2h、3h。高浓度实验组灌胃50mg/kg山奈酚+50mg/kg甘草次酸,低浓度实验组灌胃25mg/kg山奈酚+50mg/kg甘草次酸。对照组只灌胃等剂量的山奈酚。灌胃给药后分别于1h、2h和3h用摘眼球取血法取血,取血后立即处死大鼠,取出心、肝、肺、肾、脑组织,组织经处理后用HPLC法测定。结果:在肝脏、肾、肺、心中,灌胃山奈酚+甘草次酸后的组织样品的山奈酚含量与单独灌胃山奈酚的组织含量之间无显著差异。结论:甘草次酸对山奈酚在肝脏、肾、肺、心的分布没有影响。
Objective: To study the effects of glycyrrhetinic acid on pharmacokinetics of kaempferol in rats. Methods: 78 SD rats were randomly divided into 4 groups, male and female, that is, high concentrations of experimental group and low concentrations of experimental group and control group of high concentration group and low concentration group, each group also includes three groups that 1h , 2h, 3h. The high concentration experimental group was fed with 50mg / kg kaempferol + 50mg / kg glycyrrhetinic acid, and the low concentration experimental group was fed with 25mg / kg kaempferol + 50mg / kg glycyrrhetinic acid. The control group was orally gavaged with equal doses of kaempferol. Rats were sacrificed immediately after taking gavage at 1h, 2h and 3h respectively. Blood samples were taken from the rats and hearts, liver, lungs, kidneys and brain tissues were removed. The tissues were processed and determined by HPLC. Results: There was no significant difference in the content of kaempferol between the kaempferol + glycyrrhetinic acid and liver tissue in the liver, kidney, lung and heart. Conclusion: Glycyrrhetinic acid has no effect on the distribution of kaempferol in liver, kidney, lung and heart.