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对茶叶提取物茶黄色素的急性毒性、蓄积毒性和致突变作用进行了研究。结果表明：茶黄色素属基本无毒类；无明显蓄积作用；但大鼠和小鼠经口染毒均可见明显中枢神经系统中毒症状和肺弥漫性出血灶；茶黄色素３７５、７５０、１５００ｍｇ／ｋｇ剂量组小鼠骨髓ＰＣＥ微核率分别为２．０‰，２．８‰．２．４‰，与阴性对照组（２．８‰）相比均无显著性差异；Ａｍｅｓ实验中３１２．５μｇ、６２５μｇ、１２５０μｇ、２５００μｇ５０００μｇ／皿各剂量组ＴＡ９７、ＴＡ９８、ＴＡ１００、ＴＡ１０２等不同菌株加与不加Ｓ９ＭＲ均小于２；茶黄色素３７５、７５０１５００ｍｇ／ｋｇ各剂量组小鼠睾丸级精母细胞染色体畸变率与对照组比较无明显差异，而１５００ｍｇ／ｋｇ剂量组小鼠睾丸初级精母细胞性染色体单价体（４．８％）和常染色体单价体（５．６％）与对照组（２．５％，２．５％）比较有显著差异。
Acute toxicity, accumulation toxicity and mutagenicity of tea extract tea pigment were studied. The results showed that: theophylline is basically non-toxic; no significant accumulation; but rats and mice were exposed to oral CNS poisoning symptoms were obvious and diffuse pulmonary hemorrhage; tea yellow pigment 375,750,1500 mg / Kg dose group mice bone marrow PCE micronucleus rates were 2.0 ‰, 2.8 ‰. 2.4 ‰ and no significant difference compared with the negative control group (2.8 ‰); Ames test 312.5μg, 625μg, 1250μg, 2500μg5000μg / dish different doses of TA97, TA98, TA100, TA102 other strains The chromosomal aberration rate of testicular spermatocytes in the groups with or without S9MR was less than 2. There was no significant difference in the chromosomal aberration between the test group and the control group in the doses of 375, 7501500 mg / kg, while the dose of 1500 mg / Cell chromosome monovalent (4.8%) and autosomal monovalent (5.6%) compared with the control group (2.5%, 2.5%) were significantly different.