论文部分内容阅读
应用LongPCR及PrimerShiftLongPCR技术对3例肥厚型心肌病(HCM)患者和10例正常引产胎儿的13份心肌标本予以线粒体DNA缺失检测,结果在1例HCM患者心肌线粒体DNA中发现约50kb缺失,而在正常引产胎儿的标本未见该缺失,提示HCM的发生可能与mtDNA缺失相关
Mitochondrial DNA deletions were detected in 13 myocardial samples of 3 hypertrophic cardiomyopathy (HCM) patients and 10 normal fetus fetuses with LongPCR and PrimerShiftLongPCR. The results showed that about 50kb deletion was found in mitochondrial DNA of 1 HCM, However, this deletion was not observed in normal fetus fetuses, suggesting that the occurrence of HCM may be related to the deletion of mtDNA