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目的探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)病理组织中γ-选择素(γ-catenin/Plakoglobin)、原癌蛋白c-Myc和血管内皮生长因子(vascular endothelial growth factor,VEGF)的表达及其与患者预后的关系。方法应用免疫组化方法测定57例NSCLC和14例肺部良性病变病理切片中γ-catenin、c-Myc和VEGF的表达,并对γ-catenin、c-Myc和VEGF的表达与患者的性别、年龄、瘤体大小、病理类型、组织分化程度、临床分期、淋巴结转移情况及生存时间进行统计分析。结果 57例NSCLC中γ-catenin异常表达率和c-Myc的过度表达率分别为66.67%和64.91%,VEGF的阳性表达率为77.19%;14例肺部良性病变均未见γ-catenin的异常表达和c-Myc的过度表达,VEGF有3例为“±”。γ-catenin的异常表达和c-Myc的过度表达有显著相关性,c-Myc的过度表达和VEGF的阳性表达有显著相关性。γ-catenin的异常表达与肿瘤的分化程度及淋巴结转移有关(P<0.05);c-Myc的过度表达与瘤体大小及淋巴结转移有关(P<0.05);VEGF的阳性表达与瘤体大小及淋巴结转移有关(P<0.05),而与在不同临床分期及病理类型之间无统计学意义(P>0.05)。结论检测γ-catenin、c-Myc和VEGF在NSCLC中的表达变化是判断恶性肿瘤程度、浸润转移的有效参考指标,γ-catenin异常表达和c-Myc的过度表达可能影响NSCLC患者的预后。
Objective To investigate the expression of γ-catenin / c-Myc and vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC) Expression and its relationship with the prognosis of patients. Methods The expressions of γ-catenin, c-Myc and VEGF in 57 cases of NSCLC and 14 cases of benign pulmonary lesion were detected by immunohistochemistry. The expressions of γ-catenin, c-Myc and VEGF were compared with the gender, Age, tumor size, pathological type, degree of tissue differentiation, clinical stage, lymph node metastasis and survival time were statistically analyzed. Results The positive rates of γ-catenin and c-Myc in over-expression of c-Myc in 57 cases of NSCLC were 66.67% and 64.91%, respectively. The positive rate of VEGF was 77.19%. No abnormality of γ-catenin was found in all of the 14 cases Overexpression of c-Myc and VEGF in 3 cases were “±”. There was a significant correlation between the abnormal expression of γ-catenin and overexpression of c-Myc. The overexpression of c-Myc was positively correlated with the positive expression of VEGF. The abnormal expression of γ-catenin correlated with tumor differentiation and lymph node metastasis (P <0.05). The overexpression of c-Myc was correlated with tumor size and lymph node metastasis (P <0.05). The positive expression of VEGF correlated with tumor size, Lymph node metastasis (P <0.05), but not between the different clinical stages and pathological types (P> 0.05). Conclusion Detecting the expression changes of γ-catenin, c-Myc and VEGF in NSCLC is a useful reference index to judge the degree of malignant tumor and invasion and metastasis. The abnormal expression of γ-catenin and overexpression of c-Myc may affect the prognosis of patients with NSCLC.