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作者对曾接种过乙型肝炎疫苗的156名塞内加尔婴幼儿,在使用免疫加强剂后2～6年间进行了抗-HBs抗体持续存在的观察。乙型肝炎疫苗接种开始于1978年。所用疫苗为福马林灭活的ad和ay亚型等比例混合的纯化HBsAg。每个婴幼儿免疫注射3次,每次间隔1月。1年后注射1次免疫加强剂(氢氧化铝为佐剂,巴斯德疫苗厂生产的乙型肝炎疫苗作为第二次加强剂)。用放射免疫法(RIA)检测HBsAg,抗-HBc及抗-HBs。并对抗-HBs阳性标本进行定量分析,结果每毫升以毫国际单位(mIU/ml)计算。在第一次注射后,对156名接种者进行
The authors observed 156 anti-HBs antibodies persisted in 156 Senegalese infants who had been vaccinated against hepatitis B vaccine two to six years after using immunostimulants. Hepatitis B vaccination began in 1978. The vaccine used is a mixture of purified HBsAg in equal proportions of the formalin and ay subtypes of fumarin inactivated. Each infants immunized three times, at intervals of January. One year later, an immunostimulant (aluminum hydroxide adjuvant, Hepatitis B vaccine produced by the Pasteur Vaccine Factory) was injected as a second booster. HBsAg, anti-HBc and anti-HBs were detected by radioimmunoassay (RIA). And anti-HBs positive specimens for quantitative analysis, the results per milliliter milli International Units (mIU / ml) calculation. After the first injection, 156 were vaccinated