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目的:探讨应用韧致辐射原理监测亲骨放射性药物89Sr在人体的分布及其可行性。方法:以2个相同规格、分别装有37MBq的89Sr及99Tcm的玻璃瓶为模型,进行89Sr模型韧致辐射能谱等实验,以确定韧致辐射显像的最佳能量参数。对89Sr治疗后2天～4天的20例患者进行韧致辐射显像,并与99Tcm-MDP骨扫描图比较。结果:89Sr模型与静脉注射89Sr后人体韧致辐射能谱一致,均为多峰连续曲线,其主峰能量约为85KeV。89Sr模型韧致辐射显像的最佳能量、窗宽为85KeV/100%。用实验的能量参数在人体可得到89Sr韧致辐射图像。结论:利用韧致辐射显像能够监测纯β发射体89Sr在体内的分布状况。
Objective: To explore the application of bremsstrahlung principle to monitor the distribution and feasibility of human 89Sr radioactive drug in human body. Methods: Two 89Sr and 99Tcm glass bottles with the same size and 37MBq respectively were used as the models to study the bremsstrahlung spectrum of 89Sr model to determine the best energy parameters of bremsstrahlung imaging. Twenty patients undergoing 2-day to 4-day treatment of 89Sr were subjected to bremsstrahlung radiography and compared with 99Tcm-MDP bone scan. RESULTS: The 89Sr model was consistent with the bremsstrahlung spectrum of human body after 89Sr intravenous injection, all of them were multimodal continuous curves with the main peak energy of about 85KeV. 89Sr bremsstrahlung imaging best energy, window width of 85KeV / 100%. The 89Sr bremsstrahlung image can be obtained in the human body with experimental energy parameters. CONCLUSIONS: Bremsstrahlung radiometric imaging can monitor the distribution of 89Sr in pure beta emitters.