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目的和方法 :强直电刺激 (6 0Hz ,0 .4～ 0 .6mA ,2s)左、右侧背侧海马或中部颞叶新皮质制作慢性大鼠癫痫模型 ,观察大鼠行为、EEG、深部电图以及各脑区T2 (质子横向驰豫时间 )加权核磁共振成象 (T2 MRl)结构改变 ,研究海马 内嗅皮质 颞叶新皮质 大脑皮层神经通路在诱发颞叶癫痫中的可能作用。结果 :右侧海马刺激组的原发性、继发性湿狗样抖动及癫痫“点燃”效应的发生率明显高于左海马和左、右颞叶新皮质实验组 (P <0 .0 5 ,P <0 .0 0 1 ) ,部分脑区有不同程度T2 信号增强 ;少数颞叶新皮质刺激大鼠出现脑区T2 信号强度明显增强现象 ;各组脑区T2 MRI信号强度增强与行为发作和癫痫点燃效应之间具有相关关系。结论 :海马是颞叶癫痫发生和扩布的“发源地” ;而EC可能具有“门控”作用
Purpose and Methods: Chronic rat epilepsy model was made by tonic (60 Hz, 0.4-0.6mA, 2s) left and right dorsal hippocampus or middle temporal lobe neocortex. The rats’ behavior, EEG, (T2MR1) T2 pattern in each brain region to study the possible role of the neural cortex in the temporal cortex of the temporal cortex of the hippocampus in the induction of temporal lobe epilepsy. Results: The incidences of primary, secondary wet dog-like jitter and “ignition” of epilepsy in the right hippocampal stimulation group were significantly higher than those in the left hippocampus and left and right temporal cortex neocortex (P <0.05) , P <0.01). T2 signal enhancement was observed in some brain regions. T2 signal intensity in brain regions increased significantly in a small number of temporal lobe neocortical rats. The signal intensity of T2 MRI in brain regions increased and behavioral attack And epileptic lighting effects have a correlation between. Conclusion: The hippocampus is the “birthplace” of temporal lobe epilepsy. And EC may have “gating” effect