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目的探讨富于巨细胞的孤立性纤维性肿瘤(GR-SFT)的临床病理特征和鉴别诊断。方法用常规病理学检查和免疫组化方法 ,观察2例富于巨细胞的孤立性纤维性肿瘤的临床特点、病理学特征、免疫表型和鉴别诊断,并结合文献复习进行总结。结果肿瘤界限清楚,在孤立性纤维肿瘤组织学改变的基础上,具有灶性或广泛分布的多核巨细胞;多核巨细胞的形态和分布具有特征性,多分布于单核间质细胞稀疏、胶原化明显的区域。多核巨细胞和单核间质细胞CD34、CD99和bcl-2阳性。结论 GR-SFT是孤立性纤维性肿瘤的一种特殊类型,主要发生于40岁的成人,女性略多见。多核巨细胞的形态、分布和免疫表型具有诊断意义。需与巨细胞血管纤维瘤、巨细胞纤维母细胞瘤、纤维组织细胞瘤、丛状纤维组织细胞瘤、软组织巨细胞瘤、恶性纤维组织细胞瘤(多形性未分化肉瘤)等良、恶性肿瘤相鉴别。巨细胞分化是瘤组织的一种退行性改变。
Objective To investigate the clinicopathological features and differential diagnosis of giant cell-rich solitary fibrous tumor (GR-SFT). Methods The clinical features, pathological features, immunophenotypes and differential diagnosis of 2 giant cell solitary fibrous tumors were observed by routine pathological examination and immunohistochemistry. Results The tumor was well-defined. On the basis of histological changes of solitary fibrous tumor, there were focal or widespread multinucleated giant cells. The morphology and distribution of multinucleated giant cells were characterized by sparse distribution of mononuclear stromal cells, Clear the area. Multinucleated giant cells and mononuclear stromal cells are positive for CD34, CD99 and bcl-2. Conclusions GR-SFT is a special type of solitary fibrous tumor, which occurs mainly in adults aged 40 years and is more common in women. The morphology, distribution and immunophenotyping of multinucleated giant cells have diagnostic significance. Need with giant cell angiofibroma, giant cell fibroblastoma, fibrous histiocytoma, plexiform fibrous histiocytoma, soft tissue giant cell tumor, malignant fibrous histiocytoma (pleomorphic undifferentiated sarcoma) and other benign and malignant tumors Phase identification. Giant cell differentiation is a degenerative change in tumor tissue.