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目的探讨胰岛自身抗体检测在2型糖尿病(T2DM)视网膜病变发生发展中的意义。方法根据眼底荧光造影检查,将211例T2DM患者分为背景期视网膜病变(A组)、增殖期视网膜病变(B组)和无视网膜病变(C组)三组。检测血清胰岛细胞抗体(ICA)、谷氨酸脱羧酶抗体(GADA)、胰岛细胞抗原2抗体(IA-2A)、胰岛素抗体(IAA)的阳性率及糖化血红蛋白(HbA1c)水平。结果 A、B组GADA阳性率高于C组(P<0.01),且B组GADA阳性率高于A组(P<0.05);C组ICA阳性率高于B组(P<0.01);A、B组HbA1c水平高于C组(P<0.01),且B组的HbA1c水平高于A组(P<0.01)。结论胰岛自身抗体检测及血糖控制状况有助于评估T2DM视网膜病变程度。
Objective To investigate the significance of detection of islet autoantibodies in the development of type 2 diabetic (T2DM) retinopathy. Methods According to fundus fluorescein angiography, 211 patients with T2DM were divided into three groups: background retinopathy (group A), proliferative retinopathy (group B) and no retinopathy (group C). The positive rates of serum islet cell antibody (ICA), glutamic acid decarboxylase antibody (GADA), islet cell antigen 2 antibody (IA-2A) and insulin antibody (IAA) and the level of HbA1c were detected. Results The positive rate of GADA in group A and B was higher than that in group C (P <0.01), and the positive rate of GADA in group B was higher than that in group A (P <0.05). The positive rate of ICA in group C was higher than that in group B (P <0.01) , HbA1c level in group B was higher than that in group C (P <0.01), and the level of HbA1c in group B was higher than that in group A (P <0.01). Conclusion The detection of islet autoantibodies and glycemic control help to evaluate the degree of T2DM retinopathy.