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目的：观察胰岛素（ Ｉｎｓ）对高血压动脉硬化大鼠脑梗死的疗效。方法：５０ 只肾血管性高血压大鼠（ Ｒ Ｈ Ｒ）复制成大脑中动脉闭塞（ Ｍ Ｃ Ａｏ）模型，随机分４ 组： Ａ 组１２ 只（ Ｉｎｓ ２１ Ｕ／ｋｇ）， Ｂ组１２ 只〔 Ｉｎｓ ２１ Ｕ／ｋｇ＋ ５０％ 葡萄糖（２ ｇ／ｋｇ）〕， Ｃ组 １２ 只〔 Ｉｎｓ ４５ Ｕ／ｋｇ＋ ５０％ 葡萄糖（４ ｇ／ｋｇ）〕和 Ｄ组 １４ 只（生理盐水 ４ ｍ ｌ／ｋｇ）。各组均于 Ｍ Ｃ Ａｏ 后即注射胰岛素， Ｍ Ｃ Ａｏ 后 ４ 小时和２４ 小时检查神经功能，２４ 小时处死大鼠取脑，测大脑体积和梗死灶体积。结果： Ａ 组的血糖较其他组有统计学意义的下降（ Ｐ均＜ ００１）， Ｃ组的神经功能障碍评级、梗死灶体积及其与大脑体积的百分比的减少都有统计学意义（ Ｐ 均＜ ００１）， Ａ、 Ｂ、 Ｄ组间比较则无差异（ Ｐ 均＞００５）。结论：胰岛素对缺血脑组织具有不依赖于其降糖作用的直接保护作用， Ｒ Ｈ Ｒ Ｍ Ｃ Ａｏ 后注射胰岛素在较高剂量时才显示疗效，这可能与高血压致脑血管发生病变有关。
Objective: To observe the effect of insulin on cerebral infarction in hypertensive atherosclerotic rats. Methods: Fifty renovascular hypertensive rats (R H R) were duplicated into middle cerebral artery occlusion (M C Ao) model and were randomly divided into 4 groups: 12 in group A (Ins 2 1 U / kg), B 12 (Ins 2 1 U / kg + 50% glucose (2 g / kg)], 12 rats in group C (Ins 4 5 U / kg + 50% glucose 4 g / Brine 4 ml / kg). The rats in each group were injected with insulin immediately after M C Ao. Neurological function was examined at 4 and 24 hours after M C Ao. The brains of rats were sacrificed at 24 hours, and the brain volume and infarct volume were measured. Results: The blood glucose in group A was significantly lower than those in other groups (all P <001). The scores of neurological dysfunction, the volume of infarction and the percentage of brain volume in group C were significantly decreased (P < P <001). There was no difference between A, B and D groups (P> 0.05). CONCLUSION: Insulin has a direct protective effect on ischemic brain tissue independent of its hypoglycemic effect. Insulin injected at R H R M C Ao shows efficacy at higher doses, which may be related to the pathogenesis of hypertension-induced cerebrovascular disease .