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对８１例经胃镜检查和幽门螺旋菌试验确诊的顽固性十二指肠球部溃疡患者，无选择地随机分成两组进行药效对比观察。一组４２例为口服庆大霉素治疗组；另一组３９例为口服甲氰咪胍治疗组，两组患者的性别、年龄和溃疡面积大致相同。结果：幽门螺旋菌的清除率，庆大霉素组为９５．２３％，甲氰咪胍组为２．５６％；治愈率，庆大霉素组为８３．３３％，甲氰咪胍仅为４８．７１％，经统计处理两组有显著差异（Ｐ＜０．０５）。说明：庆大霉素对多种抗溃疡药物疗效较差的幽门螺旋菌相关性顽固性十二指肠球部溃疡有明显疗效。
Eighty-one patients with intractable duodenal ulcer diagnosed by gastroscopy and Helicobacter pylori were randomly divided into two groups to compare their efficacy. A group of 42 patients were treated with gentamicin; the other 39 patients were treated with oral cimetidine. The gender, age, and ulcer area of the two groups were approximately the same. Results: The clearance rate of Helicobacter pylori was 95.23% in gentamicin group and 2.56% in cimetidine group. The cure rate was 83.33% in gentamicin group. 48.71%, there was a significant difference between the two groups by statistical processing (P <0.05). Description: Gentamycin on a variety of anti-ulcer drugs less effective Helicobacter pylori-related intractable duodenal ulcer with significant effect.