AIM:To assess gallbladder emptying and its association with cholecystitis and abdominal pain in patients with primary sclerosing cholangitis(PSC).METHODS:Twenty patients with PSC and ten healthy subjects were investigated.Gallbladder fasting volume, ejection fraction and residual volume after ingestion of a test meal were compared in patients with PSC and healthy controls using magnetic resonance imaging.Symptoms, thickness and contrast enhancement of the gallbladder wall and the presence of cystic duct strictures were also assessed.RESULTS:Median fasting gallbladder volume in patients with PSC [67(19-348) mL] was twice that in healthy controls [32(16-55) mL](P < 0.05).The median postprandial gallbladder volume in patients with PSC was signiflcantly larger than that in healthy controls(P < 0.05).There was no difference in ejection fraction, gallbladder emptying volume or mean thickness of the gallbladder wall between PSC patients and controls.Contrast enhancement of the gallbladder wall in PSC patients was higher than that in controls;(69% ± 32%) and(42% ± 21%)(P < 0.05).No significant association was found between the gallbladder volumes and occurrence of abdominal pain in patients and controls.CONCLUSION:Patients with PSC have increased fasting gallbladder volume.Gallbladder Mucosal dysfunction secondary to chronic cholecystitis, may be a possible mechanism for increased gallbladder. AIM: To assess gallbladder emptying and its association with cholecystitis and abdominal pain in patients with primary sclerosing cholangitis (PSC). METHODS: Twenty patients with PSC and ten healthy subjects were investigated. Gallbladder fasting volume, ejection fraction and residual volume after ingestion of a test meal were compared in patients with PSC and healthy controls using magnetic resonance imaging. Symptoms, thickness and contrast enhancement of the gallbladder wall and the presence of cystic duct strictures were also assessed .RESULTS: Median fasting gallbladder volume in patients with PSC [67 ( 19-348) mL] was twice that in healthy controls [32 (16-55) mL] (P <0.05) .The median postprandial gallbladder volume in patients with PSC was signiflcantly larger than that in healthy controls (P <0.05). There was no difference in ejection fraction, gallbladder emptying volume or mean thickness of the gallbladder wall between PSC patients and controls. Contrast enhancement of the gallbladder wal (69% ± 32%) and (42% ± 21%) (P <0.05) .No significant association was found between the gallbladder volumes and occurrence of abdominal pain in patients and controls .CONCLUSION: Patients with PSC have increased fasting gallbladder volume. Gallbladder Mucosal dysfunction secondary to chronic cholecystitis, may be a possible mechanism for increased gallbladder.