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研究目的探讨川芎嗪对糖尿病慢性并发症的治疗效果。研究背景微循环障碍是糖尿病慢性并发症发生发展的基础。改善微循环和血液流变学异常是治疗糖尿病慢性并发症的主要方法之一。研究方法将患者分为非川芎嗪治疗组(C组)和川芎嗪治疗组(川组)。川组患者采用川芎嗪320～400mg/天加液中静滴,2周为1疗程,多数患者治疗1～2疗程。研究结果治疗多发性末梢神经病变92例,总有效率为88.0％,明显高于C组(29.0％,P<0.005);治疗视网膜病变49例,总有效率为81.6％,也明显高于C组(25.0％,P<0.005)。同时,川芎嗪可明显改善患者的血液流变学异常。结论大剂量川芎嗪静滴是治疗糖尿病慢性并发症的有效方法之一。
Objective To investigate the therapeutic effect of ligustrazine on chronic complications of diabetes. Research Background Microcirculation is the basis for the development of chronic complications of diabetes mellitus. Improving microcirculation and hemorheology abnormalities is one of the main ways to treat chronic complications of diabetes. Methods Patients were divided into non-ligustrazine treatment group (C group) and ligustrazine treatment group (Sichuan group). Chuan group patients with tetramethylpyrazine 320 ~ 400mg / day plus liquid infusion, 2 weeks for a course of treatment, the majority of patients treated 1 to 2 courses. The results of treatment of multiple peripheral neuropathy in 92 cases, the total effective rate was 88.0%, significantly higher than the C group (29.0%, P <0.005); treatment of retinopathy in 49 cases, the total effective rate was 81.6%, also significantly higher than the C group (25.0%, P <0.005). At the same time, ligustrazine can significantly improve the patient’s hemorheology abnormalities. Conclusion High-dose tetramethylpyrazine intravenous infusion is one of the effective methods for the treatment of chronic complications of diabetes.