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目的:探讨乳腺癌组织中survivin基因和c-erbB-2基因的表达与预后的关系。方法:用免疫组化S-P法检测80例乳腺癌组织中survivin、c-erbB-2的表达,分析其与腋淋巴结转移和5年无病生存率之间的关系。结果:survivin基因在乳腺癌中阳性表达率为68.75%(55/80)、c-erbB-2基因阳性表达率为36.25%(29/80),均与腋淋巴结转移正相关,与5年生存率负相关(P<0.05);survivin和c-erbB-2表达与肿瘤病理类型、发病年龄、临床分期无明显相关性(P>0.05);survivin和c-erbB-2基因表达相互呈正相关(P<0.05)。结论:凋亡抑制基因survivin和原癌基因c-erbB-2可能在乳腺癌的发生、发展过程中起重要作用,联合检测能更好地判断乳腺癌的预后。
Objective: To investigate the relationship between the expression of survivin gene and c-erbB-2 gene and prognosis in breast cancer. Methods: The expressions of survivin and c-erbB-2 in 80 cases of breast cancer were detected by immunohistochemical S-P method. The relationship between the expression of survivin and c-erbB-2 in axillary lymph node metastasis and 5 year disease-free survival rate was analyzed. Results: The positive rate of survivin gene in breast cancer was 68.75% (55/80) and the positive rate of c-erbB-2 gene was 36.25% (29/80), all of which were positively correlated with axillary lymph node metastasis and 5-year survival (P <0.05). The expressions of survivin and c-erbB-2 had no significant correlation with tumor pathological type, age of onset and clinical stage (P> 0.05). The expressions of survivin and c-erbB- P <0.05). Conclusion: The apoptosis-suppressing gene survivin and proto-oncogene c-erbB-2 may play an important role in the occurrence and development of breast cancer. Combined detection can better predict the prognosis of breast cancer.