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过去对消化道运动调节机制的研究主要是围绕神经因索进行的。但自Bayliss、Starling等发现肠促胰液素,Edkins发现胃泌素之后,相继发现了由消化道产生的肽激素,缩胆囊素——肠促胰酶素(CCK-PZ)、血管活性肠多肽激素(VIP)、胃抑制多肽(GIP)以及胃动素(Motilin)等,使我们了解消化运动的调节与消化道激素有关。胃肠粘膜细胞除分泌消化道激素外,并分泌5—羟色胺、儿茶酚胺、组织胺等物质。上述物质是由消化道粘膜上皮的基底颗粒细胞分泌产生的。由于基底颗粒细胞在形态、代谢与
In the past, the research on the regulation mechanism of gastrointestinal motility mainly focused on the neurological factors. However, since the discovery of incretin by Bayliss and Starling et al., And the discovery of gastrin by Edkins, one has been found to produce the peptide hormone, cholecystokinin-enteromachinase (CCK-PZ), vasoactive intestinal polypeptide VIP, GIP, Motilin and so on, so that we understand the regulation of digestive movement and gastrointestinal hormones. Gastrointestinal mucosal cells in addition to the secretion of digestive tract hormones, and the secretion of serotonin, catecholamines, histamine and other substances. The above substances are secreted by basal granulosa cells in the mucosal epithelium of the alimentary tract. Due to the basal granulosa cells in morphology, metabolism and