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本文通过自然吸入染尘制备矽肺大鼠模型，研究大鼠肺局部免疫功能的变化。结果表明吸入石英粉尘后动物血清中ＩｇＧ水平、肺灌洗液ＩｇＧ、ＩｇＭ含量、肺灌洗液、肺组织、肺引流淋巴结中总细胞数、淋巴细胞数，肺引流淋巴结中ＣＤ３＋、ＣＤ４＋、Ｂ淋巴细胞数显著高于二氧化钛和／或单纯空气组。实验说明矽肺动物肺局部出现免疫球蛋白上升、淋巴细胞尤其是ＣＤ４＋和Ｂ细胞数异常增多等现象。提出矽肺肺脏细胞免疫功能减弱的原因可能与肺组织以及肺引流淋巴结中Ｔｈ细胞亚群数量和比例异常有关的假设。
In this paper, silicosis rat model was prepared by natural inhalation of dust to study the changes of local lung immune function. The results showed that the levels of IgG in serum, IgG, IgM in lung lavage fluid, lung lavage fluid, lung tissue, the total number of pulmonary draining lymph nodes, lymphocyte count, CD3 +, CD4 +, B The number of lymphocytes was significantly higher than that of titanium dioxide and / or simple air group. Experiments show that the appearance of immunoglobulin in the lungs of silicosis increased, especially lymphocytes, especially the abnormal increase of CD4 + and B cells. It is proposed that the reason for the diminished immunological function of silicosis lung cells may be related to the hypothesis that the number and proportion of Th cell subsets in lung tissue and pulmonary draining lymph nodes are abnormal.