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目的:综合评价双黄连注射剂治疗小儿肺炎的临床疗效及安全性。方法:系统检索Springer、Pub Med、the Cochrane Library、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、中国生物医学文献数据库(Sino Med)、万方数据库等数据库19792016年6月1日文献,全面搜集双黄连注射剂治疗小儿肺炎的随机对照试验,对纳入文献进行质量评价,提取资料并通过RevMan 5.3软件进行数据分析。结果:共纳入19篇文献,累计3 133例受试者。Meta分析结果显示:在常规用药的基础上,联合使用双黄连注射剂可提高临床总有效率(RR=1.14,95%CI:1.10 1.19,P<0.000 01)。此外,双黄连注射剂还可缩短退热时间、止咳时间、啰音消失时间等,且未见严重的不良反应发生。结论:临床上使用双黄连注射剂治疗小儿肺炎具有一定的疗效,但其安全性仍需进一步探讨。
Objective: To evaluate the clinical efficacy and safety of Shuanghuanglian injection in children with pneumonia. METHODS: Databases such as Springer, Pub Med, the Cochrane Library, Chinese Journal Full-text Database (CNKI), Chinese Scientific and Technical Periodicals VIP Database, Sino Med, Wanfang Database were searched systematically. Day literature, a comprehensive collection of Shuanghuanglian injection for the treatment of pneumonia in children with randomized controlled trials, the quality of the literature included in the evaluation, extraction of data and the RevMan 5.3 software for data analysis. RESULTS: A total of 19 articles were included, with a total of 3,133 subjects. The results of Meta analysis showed that the combination of shuanghuanglian injection can improve the total clinical effective rate (RR = 1.14, 95% CI: 1.10 1.19, P <0.000 01) on the basis of routine medication. In addition, Shuanghuanglian injection can shorten the antipyretic time, cough time, rales disappear time, and no serious adverse reactions. Conclusion: Shuanghuanglian injection in clinical treatment of children with pneumonia has a certain effect, but its safety remains to be further explored.