多种药物可以直接或间接引起肾脏病变,其发生率报告不一,少则占肾病的5%,多则高达20～25%。因此,在临床诊断和治疗中必须对药原性肾脏疾病给予足够的重视。一、药物的体内分布与排泄药物被吸收入血后,仅一部分呈游离状态的药物到达作用部位,并与组织的受体发生反应。大部分药物与血浆蛋白结合或与组织非特异性地结合。血液中的游离药物与以上三种途径保持动态平衡,并以原形 A variety of drugs can cause kidney disease directly or indirectly, the incidence of different reports, ranging from 5% of kidney disease, as many as as high as 20 to 25%. Therefore, in clinical diagnosis and treatment must pay enough attention to the drug-induced renal disease. First, the distribution and excretion of drugs in the body After the drug is absorbed into the blood, only part of the drug is free to reach the site of action, and with the organization’s receptor reaction. Most drugs bind to plasma proteins or non-specifically bind to tissues. Free drugs in the blood and the above three ways to maintain a dynamic balance, and the prototype