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目的研究黄芪注射液配合环磷酰胺治疗难治性肾病综合征的临床疗效。方法对 6 8例激素抵抗或激素依赖患者联合应用泼尼松片 1mg/(kg·d) ,环磷酰胺针 0 .2 g,隔日静注 ,其中 40例加用黄芪注射液 40 ml(相当于生药 12 g) ,1次 /d,静点 ,比较治疗前后血生化指标及尿 2 4小时蛋白量。结果治疗 12周时 ,两组血浆白蛋白均明显上升 (P<0 .0 1) ,黄芪组较对照组升高更显著 (P<0 .0 5 ) ,而黄芪组 TG、TC明显下降 (P<0 .0 1) ,复发率相对低 (P<0 .0 5 ) ,感染发生率较低 (P<0 .0 5 )。完全缓解 15例 ,部分缓解 18例 ,无效 7例 ,有效率比对照组高 ,但无显著差异。结论黄芪注射液配合环磷酰胺治疗难治性肾病综合征安全有效 ,且复发率低 ,尚可调节血脂代谢。黄芪在肾病综合征治疗中地位有待进一步探讨。
Objective To study the clinical efficacy of Astragalus injection combined with cyclophosphamide in the treatment of refractory nephrotic syndrome. Methods A total of 68 patients with steroid resistance or hormone dependence were treated with 1 mg / (kg · d) of prednisone and 0.2 g of cyclophosphamide respectively, followed by intravenous injection every other day. 40 of them were given Astragalus injection 40 ml The crude drug 12 g), 1 time / d, static point, compared before and after treatment of blood biochemical indicators and urinary 24 hours of protein. Results After 12 weeks of treatment, plasma albumin increased significantly in both groups (P <0.01), while in Astragalus group increased more significantly than that in control group (P <0.05), while TG and TC in Astragalus decreased P <0.01). The relapse rate was relatively low (P <0.05), and the infection rate was lower (P <0.05). Complete remission in 15 cases, partial remission in 18 cases, 7 cases, the effective rate higher than the control group, but no significant difference. Conclusion Astragalus injection combined with cyclophosphamide in the treatment of refractory nephrotic syndrome is safe and effective, and the recurrence rate is low, it can regulate blood lipid metabolism. Astragalus in the treatment of nephrotic syndrome status to be further explored.