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以镁铝水滑石为主体,以抗炎药萘普生为客体,采用分置镁、铝源、由共沉淀法和离子交换法合成得到超分子复合结构材料-萘普生插层镁铝水滑石。用XRD,FT-IR,TG-DTA对合成产物进行了表征。结果表明:客体萘普生阴离子是以短轴单层垂直的方向插于层间;TG-DTA结果表明,萘普生与主体之间通过氢键和静电场效应相互作用,从而使其热稳定性明显提高。同时,考查了萘普生插层的柱状水滑石分别在蒸馏水、生理盐水、模拟胃液(pH 4.60)及模拟肠液(pH 7.43)中的缓释性能,结果表明:萘普生在不同pH的溶液中,缓释机理不同;在pH 7.43模拟肠液中,具有较强的缓释性能,而在pH 4.60模拟胃液中释放度最大,但缓释性能稍差;同时,共沉淀法比离子交换法制得萘普生插层镁铝水滑石具有良好的缓释性能,且萘普生含量高释放平衡浓度大。该研究表明药物-无机混合物材料能够用作有效的药物传输系统。
Taking Mg-Al-hydrotalcite as the main body and anti-inflammatory drug Naproxen as the object, the composite magnesium and aluminum source was prepared by coprecipitation and ion-exchange method. talc. The synthesized products were characterized by XRD, FT-IR and TG-DTA. The results showed that the guest naproxen anion was intercalated vertically with the short-axis monolayer. The results of TG-DTA showed that the interaction between naproxen and the host through hydrogen bonding and electrostatic field effect made it stable Sex improved significantly. At the same time, the sustained release performance of naproxen intercalated columnar hydrotalcite in distilled water, physiological saline, simulated gastric fluid (pH 4.60) and simulated intestinal fluid (pH 7.43) were investigated. The results showed that the solution of naproxen at different pH In the simulated intestinal fluid pH 7.43, has a strong sustained release performance, while in the simulated gastric fluid pH 4.60 the release of the largest, but slightly slower release performance; the same time, coprecipitation than ion exchange method Naproxen intercalated Mg-Al hydrotalcite has good sustained-release properties, and the high content of naproxen release equilibrium concentration. This study shows that drug-inorganic mixture materials can be used as an effective drug delivery system.