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肤康凝胶是由苦参提取物、醋酸氯己定等原料制成的医院制剂,具有抑菌消炎、止痒之功效,可用于治疗皮肤瘙痒、红疹、湿疹等症。制剂中醋酸氯己定具有良好的杀灭微生物作用,被广泛用于各种皮肤消毒剂配方中。其含量测定方法有电位滴定法[1]、紫外分光光度法[2]、双波长分光光度法[3]、毛细管电泳高频电导法[4]和高效液相色谱法[5]等。为了控制肤康凝胶的质量,本实验采用高效液相色谱法(HPLC)测定肤康凝胶中醋酸氯己定的含量。
Fukang gel is made of Sophora extract, chlorhexidine acetate and other raw materials made of hospital preparations, with anti-bacterial anti-inflammatory, itching effect, can be used to treat skin itching, rashes, eczema embolism. Chlorhexidine acetate formulations have a good role in the killing of microorganisms, is widely used in a variety of skin disinfectant formulations. The determination of its content potentiometric titration [1], UV spectrophotometry [2], dual-wavelength spectrophotometry [3], capillary electrophoresis [4] and high performance liquid chromatography [5]. In order to control the quality of Fukang gel, the content of chlorhexidine acetate in Fukang gel was determined in this experiment by high performance liquid chromatography (HPLC).