论文部分内容阅读
本文介绍2例复发性难治性胰性霍乱(Verner-Morrison综合征)应用人白细胞干扰素治疗后迅速见效,临床症状缓解,同时血浆中肠血管活性肽(VIP)和其它多肽的浓度下降.例1:64岁男性,患I型多发性内分泌肿瘤(MEN-I)所致肾结石和高血钙,在1969年行甲状旁腺切除术.1973年出现严重水泻和低血钾,检查发现胰腺肿瘤而行手术切除.1977年又发生严重水泻,粪便量达每日2000～9000ml,并伴低血钾和无胃酸,CT扫描和血管造影证实有多个肝内转移灶,血VIP高达210pmol/L.用链脲霉素治疗3周后大便正常,肝转移灶消失,VIP浓度降至正常,以后即用链脲霉素维持治疗.1981年因肝转移灶再现,恢复治疗并加用阿霉素,
This article describes two cases of relapsed refractory pancreatic cholera (Verner-Morrison syndrome) after the application of human leukocyte interferon therapy quickly, clinical symptoms, while plasma concentrations of intestinal vasoactive peptides (VIP) and other polypeptides decreased. Example 1: 64-year-old male with kidney stones and hypercalcemia due to type I multiple endocrine tumors (MEN-I). Parathyroidectomy was performed in 1969. Severe watery diarrhea and hypokalemia occurred in 1973. Pancreatic neoplasm was discovered and surgical resection was performed. In 1977, severe watery diarrhea occurred again. The stool volume reached 2,000-9000ml per day. Hypokalemia and gastric acid were absent. CT scan and angiography confirmed multiple intrahepatic metastases. Up to 210 pmol/L. After 3 weeks of treatment with streptozotocin, the stool was normal, liver metastases disappeared, and the VIP concentration was reduced to normal. After that, treatment with streptozotocin was continued. In 1981, hepatic metastases were reconstructed and the treatment was resumed. With doxorubicin,