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目的观察阿托伐他汀联合血栓通治疗不稳定型心绞痛的疗效。方法 260例不稳定型心绞痛患者,随机分为观察组和对照组,每组130例。对照组单用阿托伐他汀治疗,观察组在对照组的基础上给予血栓通注射液治疗。比较两组血脂水平及治疗效果。结果观察组和对照组治疗总有效率分别为93.1%、85.4%,两组比较差异具有统计学意义(P<0.05)。与治疗前比较,观察组治疗后血清高密度脂蛋白胆固醇(HDL-C)水平明显升高,总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平明显降低,差异具有统计学意义(P<0.05);而对照组上述指标治疗后与治疗前比较差异无统计学意义(P>0.05);且观察组治疗后优于对照组(P<0.05)。结论血栓通具有活血化瘀、改善血液循环、稀释血液等疗效,血栓通联合阿托伐他汀可以提高降血脂作用,临床上两种药物联合使用治疗不稳定型心绞痛具有安全、有效、相互协同作用,值得推广使用。
Objective To observe the effect of atorvastatin combined with Xueshuantong in the treatment of unstable angina pectoris. Methods 260 patients with unstable angina were randomly divided into observation group and control group, with 130 cases in each group. The control group was treated with atorvastatin alone, and the observation group was given Xueshuantong injection on the basis of the control group. Blood lipid levels and treatment effects were compared between the two groups. Results The total effective rates of the observation group and the control group were 93.1% and 85.4%, respectively. There was significant difference between the two groups (P <0.05). Compared with those before treatment, the levels of serum high density lipoprotein cholesterol (HDL-C) and total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) (P <0.05). However, there was no significant difference between the above indexes in the control group and before treatment (P> 0.05). The observation group was superior to the control group after treatment (P <0.05). Conclusion Xueshuantong has the effects of promoting blood circulation and removing blood stasis, improving blood circulation and blood thinning. Xueshuantong combined with atorvastatin can improve the effect of lowering blood fat. It is safe, effective and synergistic to combine two drugs in the treatment of unstable angina pectoris , It is worth to promote use.