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发展环状化合物的高效合成方法对药物分子、天然产物及其他功能有机分子的合成具有重要意义.近年来,叔膦促进下两种亲电试剂之间的环化反应,由于具有原料简单易得、反应条件温和、且无需金属参与等优点,同时为多种碳环及杂环化合物的合成提供了高效的新途径,因而受到了合成化学家的广泛关注.这类反应通常经过叔膦对亲电试剂进行亲核加成,产生两性离子活性中间体这一关键步骤来完成.根据两性离子的不同来源,综述了叔膦促进下缺电子联烯、Morita-Baylis-Hillman烯丙基化合物、缺电子烯烃与其他亲电试剂之间的环化反应.
The development of efficient synthesis of cyclic compounds is of great importance for the synthesis of drug molecules, natural products and other functional organic molecules.In recent years, the cycloaddition reaction between two electrophiles under tertiary phosphine promoted, , Mild reaction conditions, and without the need for metal participation, etc. Meanwhile, it has provided new and efficient ways for the synthesis of a variety of carbocyclic and heterocyclic compounds and has received widespread attention from synthetic chemists, Electrophoretic nucleophilic addition, resulting zwitterionic active intermediates in this key step to complete.According to different sources of zwitterions, reviewed the tertiary electron-deficient electron-deficient alkene, Morita-Baylis-Hillman allyl compounds, lack Cyclization reaction between electron-olefins and other electrophiles.