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目的:研究美托洛尔对心理应激大鼠抗氧化功能的影响。方法:将健康成年SD大鼠随机分为对照组、模型组和美托洛尔组,空瓶刺激法建立心理应激模型。对照组每日规律喂水;模型组、美托洛尔组按随机数字表无规律喂水;对照组、模型组腹腔注射0.9%Na Cl溶液(2 m L·kg-1);美托洛尔组注射美托洛尔(2 mg·kg-1)。造模结束检测行为学变化,ELISA法测定血浆COR,Adr,NOX1,XOD水平,比色法测定血浆H2O2,CAT,SOD,GSH-PX水平。结果:模型组、美托洛尔组行为学评分及血浆COR,Adr显著增高。美托洛尔能明显降低血浆氧化因子H2O2,NOX1,XOD水平,提高抗氧化因子SOD,GSH-PX,CAT的水平。结论:美托洛尔能增强心理应激大鼠的抗氧化能力。
Objective: To study the effect of metoprolol on the anti-oxidative function of psychological stress rats. Methods: Healthy adult SD rats were randomly divided into control group, model group and metoprolol group. The empty-bottle stimulation method was used to establish psychological stress model. The rats in the model group and the metoprolol group were randomly fed according to the random number table. The control group and the model group were intraperitoneally injected with 0.9% NaCl solution (2 m L · kg -1) The group received metoprolol (2 mg · kg -1). The behavioral changes were detected at the end of modeling. The levels of COR, Adr, NOX1 and XOD in plasma were measured by ELISA. The levels of plasma H2O2, CAT, SOD and GSH-PX were measured by colorimetry. Results: The model group and metoprolol group were significantly higher in behavioral score and plasma COR and Adr. Metoprolol can significantly reduce plasma levels of oxidative factors H2O2, NOX1 and XOD, and increase the levels of antioxidants SOD, GSH-PX and CAT. Conclusion: Metoprolol can enhance the antioxidant capacity of psychological stress rats.