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目的 :分析人感染新型布尼亚病毒的临床特点和血清流行病学特征,为制定预防控制措施提供参考。方法 :依《发热伴血小板减少综合征防治指南(2010版)》诊断标准共收集17例患者,采用双抗原夹心ELISA法检测血清新型布尼亚病毒总抗体,采用实时荧光定量PCR(real-time PCR)法进行病原学诊断。结果:1996年发热伴血小板减少暴发疫情发病11例,2010年对留存的7例患者血清进行复核,5份检出新布尼亚病毒总抗体阳性;2010年对1996年疫情中的4例病例再次采样检测,4份标本新布尼亚病毒总抗体阳性。1996年疫情病例11例,2010~2012年监测发现新布尼亚病毒病例6例,合计17例病例中,死亡5例,重症1例,轻症11例,主要临床特征包括发热(100.00%)、血小板减少(100.00%)、白细胞减少(76.47%)以及出血症状、全身中毒症状等。结论:初步观察新布尼亚病毒感染患者抗体阳性可持续14年以上;该病毒感染临床上包括无症状、轻症、重症和死亡病例;主要临床特征包括发热、血小板减少、白细胞减少、出血和全身中毒症状等。
Objective: To analyze the clinical features and serum epidemiological characteristics of human infection with new Bunyavirus, and to provide a reference for the development of prevention and control measures. Methods: A total of 17 patients were collected according to the Diagnostic Criteria of Fever and Thrombocytopenia Syndrome (2010 Edition). The total anti-Bunyavirus antibody was detected by double antigen sandwich ELISA. Real-time PCR PCR) for pathogenic diagnosis. Results: The incidence of fever with thrombocytopenia in 1996 was 11 cases. In 2010, the sera of 7 remaining patients were reviewed, and 5 samples were positive for New Bunyavirus. In 2010, 4 cases were detected in the outbreak in 1996 Sampling again, 4 specimens of new Bunyavirus total antibody positive. Eleven cases of outbreaks were detected in 1996 and 6 cases of new Bunyan viruses were detected in 2010-2012. Of the 17 cases, 5 were fatal, 1 severe and 11 mild. The main clinical features included fever (100.00%), , Thrombocytopenia (100.00%), leukopenia (76.47%) and bleeding symptoms, symptoms of systemic poisoning. CONCLUSIONS: The preliminary observation of antibody positive in patients with New Bunyan virus infection can last for more than 14 years. The virus infection clinically includes asymptomatic, mild, severe and death cases. The main clinical features include fever, thrombocytopenia, leucopenia, hemorrhage and Systemic symptoms such as poisoning.