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目的 观察麻疹乙脑二联活疫苗对猴体的安全性。方法 应用麻疹乙脑二联活疫苗注射恒河猴 脑内和脊髓，以麻疹和乙脑单价苗作对照，进行临床体征和组织病理学观察以及抗体测定。结果 全部试验猴临 床体征无异常反应，组织病理学检查联苗组大脑皮质和中脑黑质、颈髓仅见轻微炎症反应，病变均＜５％，未见神经 细胞坏死现象。麻疹抗体应答较好，乙脑抗体有轻微的升高。结论 麻疹乙脑二联活疫苗的神经毒力与两种单价 苗比较未见增强。
Objective To observe the safety of measles JE co-live vaccine on monkeys. Methods The measles and JE mononuclear splenocytes were injected into the brain and spinal cord of Rhesus Monkey with live measles JE vaccine. Clinical signs, histopathological observation and antibody determination were performed. Results All the clinical signs of the monkeys showed no abnormal reaction. Histopathological examination showed only mild inflammatory reaction in the cortex and midbrain in the cortex. The lesions were all less than 5%. No neuronal necrosis was observed. Measles antibody response is good, JE antibody slightly increased. Conclusion The virulence of measles JE co-live vaccine did not increase compared with the two monovalent vaccines.