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用大剂量化疗和自体造血干细胞移植方案治疗成人难治性恶性肿瘤时,血小板植活时间(在不输血情况下,血小板值连续3天大于50×10~9/L)是评价其疗效的重要标志。作者对45例Ⅳ期乳腺癌患者进行了大剂量化疗及自体造血干细胞移植。之后有相当部分的病人出现了血小板延迟植活或未植活。这45例病人接受的大剂量化疗方案为:1.环磷酰胺+噻替哌;2.环磷酰胺+噻替哌+马尔法兰;3.环磷
When high-dose chemotherapy and autologous hematopoietic stem cell transplantation are used to treat adult refractory malignancies, the duration of platelet activation (platelet count greater than 50 × 10-9 / L for 3 consecutive days without blood transfusions) is an important measure of efficacy Sign. The authors of 45 cases of stage Ⅳ breast cancer patients underwent high-dose chemotherapy and autologous stem cell transplantation. After a considerable number of patients with delayed platelet activation or non-implantation. The 45 patients received high-dose chemotherapy regimens: 1. Cyclophosphamide + thiotepa; 2. Cyclophosphamide + thiotepa + Marfranca; 3. Cyclic phosphorus