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Antioxidants capable of inhibiting LDL oxidation may reduce atherosclerosis. Many Chinese herbs on blood stasis contain antioxidants to inhibit LDL oxidation. Caffeic acid phenethyl ester and several caffeic acid - containing analogues more potent than probucol have been identified. We conclude that lipophilic antioxidants which can incorporate into LDL with their antioxidative functionalities being exposed ahead of the bis - allylic sites of PUFA in LDL are most favorable.
Antioxidants capable of inhibiting LDL oxidation may reduce atherosclerosis. Many Chinese herbs on blood stasis contain antioxidants to inhibit LDL oxidation. Caffeic acid phenethyl ester and several caffeic acid - containing analogues more potent than probucol have been identified. We conclude that lipophilic antioxidants which can incorporate into LDL with their antioxidantative functionalities being exposed ahead of the bis - allylic sites of PUFA in LDL are most favorable.